陈朋

教授、博士生导师

邮箱：pengch@whu.edu.cn

通讯地址：湖北省武汉市武昌区东湖路185号金沙集团wwW3354CC，430071

教育经历:

2008.09 - 2013.11, 中国科学技术大学, 生物化学与分子生物学, 博士

2004.09 - 2008.07, 东北师范大学, 生物科学, 学士

研究经历:

2021.11 - 至今, 武汉大学, 金沙集团wwW3354CC, 教授

2019.05 - 2021.11, 加州大学欧文分校, 医学院/生理及生物物理系,助理项目科学家

2014.05 - 2019.05, 加州大学欧文分校，医学院/生理及生物物理系,博士后

研究方向:

1.病原菌效应因子与宿主之间相互作用分子机制研究

2.基于结构的靶向药物研发和疫苗设计

招生招聘：

1. 欢迎报考、推免本课题组硕士和博士研究生，也欢迎本科生加入实验室从事科研活动。

2. 本课题组长期招聘研究助理和博士后，欢迎来信，并附个人简历。

代表性论文(*共同第一作者，#共同通讯作者)：

1.  Chen, P^*., Tao, L^*., Wang, T., Zhang, J., He, A., Lam, K. H., Liu, Z., He, X., Perry, K., Dong, M^#. & Jin, R^#. (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B, Science. 360, 664-669.

2.  Chen, P., Lam, K. H., Liu, Z., Mindlin, F. A., Chen, B., Gutierrez, C. B., Huang, L., Zhang, Y., Hamza, T., Feng, H., Matsui, T., Bowen, M. E., Perry, K. & Jin, R. (2019) Structure of the full-length Clostridium difficile toxin B, Nature Structural & Molecular Biology. 26, 712-719.

3.  Chen, P^*., Zeng, J^*., Liu, Z., Thaker, H., Wang, S., Tian, S., Zhang, J., Tao, L., Gutierrez, C. B., Xing, L., Gerhard, Ralf., Huang, L., Dong, M^#. & Jin, R^#. (2021) Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, Nature Communications. 12, 3748.

4. Chen, P., Tao, L., Liu, Z., Dong, M. & Jin, R. (2019) Structural insight into Wnt signaling inhibition by Clostridium difficile toxin B, The FEBS Journal. 286, 874-881.

5. Chen, P., & Jin, R. (2021). Receptor binding mechanisms of Clostridioides difficile toxin B and implications for therapeutics development, The FEBS Journal. doi:10.1111/febs.16310

6. Chen, P., Liu, Z., Wang, X., Peng, J., Sun, Q., Li, J., Wang, M., Niu, L., Zhang, Z., Cai, G^#., Teng, M^#. & Li, X^#. (2015) Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations, PloS one. 10.

7. Chen, P., Li, J., Ma, J., Teng, M. & Li, X. (2013) A Small Disturbance, But a Serious Disease: The Possible Mechanism of D52H-Mutant of Human PRS1 That Causes Gout, IUBMB Life. 65, 518-525.

8.  Liu, Z., Chen, P., Wang, X., Cai, G., Niu, L., Teng, M^#. & Li, X^#. (2014) Crystal structure of DnaT(84-153)-dT10 ssDNA complex reveals a novel single-stranded DNA binding mode, Nucleic Acids Research. 42, 9470-9483.

9.  Liu, Z., Zhang, S., Chen, P., Tian, S., Zeng, J., Perry, K., Dong, M. & Jin, R. (2021) Structural basis for selective modification of Rho and Ras GTPases by Clostridioides difficile toxin B, Science Advances 7, eabi4582.

专利：

1. Vaccine compositions for Clostridium difficile. PCT/US2020/034070.

2. Compositions and methods for inhibiting wnt signaling. PCT/US2019/013440.