高帅

性别：男

职务/职称：教授/博士生导师

通讯地址：湖北省武汉市武昌区东湖路185号金沙集团wwW3354CC，430071

学习背景

2009.09 - 2013.06 山东大学，化学与化工学院，学士

2013.09 - 2018.06 清华大学，生命科学学院，博士

工作经历

2018.08-2022.07 美国普林斯顿大学，分子生物学系，博士后

2022.7-至今 武汉大学，金沙集团wwW3354CC，教授/博士生导师

成果概要

近年来已发表学术论文24篇，其中以第一作者或共同通讯身份发表文章9篇，期刊包括Nature 1篇、Nat. Commun.1篇、J. Am.Chem. Soc.2篇、PNAS 1篇、Angew. Chem. Int. Ed.2篇、Sci. China Chem.1篇，Cell Res. 1篇，并持有一项中国发明专利。

研究领域

疾病相关膜蛋白功能机制解析，膜蛋白翻译后修饰的化学生物学研究

研究兴趣与方向

1.疾病相关膜蛋白（如离子通道、转运蛋白）功能机制研究

2.膜蛋白翻译后修饰的化学生物学研究

3.靶向重要膜蛋白多肽或小分子药物开发

招生招聘

1.热忱欢迎对本实验室研究方向感兴趣的有志青年加盟！ 欢迎具有药学、化学生物学或分子生物学等背景的硕士、博士加盟，待遇从优。

2.热忱欢迎应届博士毕业生或毕业两年内的博士加盟本课题组从事博士后研究，博士后年薪30万以上，另有丰厚的科研绩效奖励。

3.欢迎本科生毕设，以及对本实验室研究感兴趣的本科生参与科研训练。

4.有意者请将简历发至邮箱：gaoshuai812@whu.edu.cn

科研成果

First Author and Corresponding Author

¨ 1.Shuai Gao^#,Xia Yao^#, Nieng Yan. “Structure of human Ca_v2.2 channel blocked by the painkiller ziconotide” (Nature, 2021, 596, 143-147)

¨ 2. Shuai Gao*, Nieng Yan*. “Structural basis of Ca_v1.1 modulation by dihydropyridine compounds” (Angew. Chem. Int. Ed. Engl. 2020, 60, 3131-3137, Corresponding Author)

¨ 3. Shuai Gao, William C. Valinsky, Nguyen Cam On, Patrick R. Houlihan, Qian Qu, Lei Liu, Xiaojing Pan, David E. Clapham, and Nieng Yan. “Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na⁺ channels in nanodisc” (Proceedings of the National Academy of Sciences. 2020, 117, 14187-14193)

¨ 4. Xia Yao^#, Shuai Gao^#, Nieng Yan. “Structural basis for pore blockade of human voltage-gated calcium channel Cav1. 3 by motion sickness drug cinnarizine” (Cell Research, 2022)

¨ 5. Yaping Pan^#*, Zhenning Ren^#,Shuai Gao^#*, Jiemin Shen^#, Lie Wang, Zhichun Xu, YeYu, Preetham Bachina, Hanzhi Zhang, Xiao Fan, Arthur Laganowsky, Nieng Yan, Ming Zhou*. “Structural basis of ion transport and inhibition in ferroportin” (Nature communications, 2020, 11, 5896, Corresponding Author)

¨ 6. Qian Qu^#, Shuai Gao^#, Fangming Wu^#, Mengge Zhang, Ying Li, Longhua Zhang, Donald Bierer, Changlin Tian, Jishen Zheng, Lei Liu. “Synthesis of disulfide surrogate peptides incorporating large-span surrogate bridges Through a Native-Chemical-Ligation-Assisted Diaminodiacid Strategy” (Angew. Chem. Int. Ed. Engl. 2020, 59, 6037-6045)

¨ 7. Chenchen Chen^#, Shuai Gao^#, Huasong Ai, Qian Qu, Changlin Tian, and Yiming Li.“Racemic X-ray structure of L-type calcium channel antagonist Calciseptine prepared by total chemical synthesis” (Science China Chemistry 2018, 61, 702-707)

¨ 8. Shuai Gao^#, Man Pan^#, Yong Zheng^#, Yichao Huang, Qingyun Zheng, Demeng Sun, Lining Lu, Xiaodan Tan, Xianglong Tan, Huan Lan, Jiaxing Wang, Tian Wang, Jiawei Wang, and Lei Liu. “Monomer/Oligomer Quasi-Racemic Protein Crystallography” (J. Am. Chem. Soc. 2016, 138, 14497−14502)

¨ 9. Man Pan^#, Shuai Gao^#, Yong Zheng^#, Xiaodan Tan, Huan Lan, Xianglong Tan, Demeng Sun, Lining Lu, Tian Wang, Qingyun Zheng, Yichao Huang, Jiawei Wang, and Lei Liu. “Quasi-Racemic X‑ray Structures of K27-Linked Ubiquitin Chains Prepared by Total Chemical Synthesis” (J. Am. Chem. Soc. 2016, 138, 7429−7435)

Co-Author

¨ 10. Renhong Yan^#, Pingping Cao^#, Wenqi Song^#, Hongwu Qian, Ximing Du, Hudson W Coates, Xin Zhao, Yaning Li, Shuai Gao, Xin Gong, Ximing Liu, Jianhua Sui, Jianlin Lei, Hongyuan Yang, Andrew J Brown, Qiang Zhou, Chuangye Yan, Nieng Yan. “A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols” (Science, 2021, 371, eabb2224)

¨ 11. Hongwu Qian^#, Xin Zhao^#, Renhong Yan^#, Xia Yao, Shuai Gao, Xue Sun, Ximing Du, Hongyuan Yang, Catherine CL Wong, and Nieng Yan. “Structural basis for catalysis and substrate specificity of human ACAT1” (Nature, 2020, 581, 333-338)

¨ 12. Man Pan^#, Qingyun Zheng^#, Shuai Gao, Qian Qu, Yuanyuan Yu, Ming Wu, Huan Lan, Yulei Li, Sanling Liu, Jiabin Li, Demeng Sun, Lining Lu, Tian Wang, Wenhao Zhang, Jiawei Wang, Yiming Li, Hong-Gang Hu, Changlin Tian, Lei Liu. “Chemical synthesis of structurally defined phosphorylated ubiquitins suggests impaired parkin activation by phosphorylated ubiquitins with a non-phosphorylated distal unit” (CCS Chemistry, 2019, 1, 476-489)

¨ 13. Zhao, Yanyu^#, Gaoxingyu Huang^#, Jianping Wu^#, Qiurong Wu, Shuai Gao, Zhen Yan, Jianlin Lei, and Nieng Yan. “Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca²⁺ Channel.” (Cell, 2019, 177, 1495-1506)

¨ 14. Qian, Hongwu^#, Pingping Cao^#, Miaohui Hu, Shuai Gao, Nieng Yan, and Xin Gong. “Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm.” (Nature communications, 2019, 10, 2320)

¨ 15. Pan, Xiaojing^#, Zhangqiang Li^#, Xiaoshuang Huang^#, Gaoxingyu Huang^#, Shuai Gao, Huaizong Shen, Lei Liu, Jianlin Lei, and Nieng Yan. “Molecular basis for pore blockade of human Na⁺ channel Na_v1.2 by the μ-conotoxin KIIIA.” (Science, 2019, 363, 1309-1313)

¨ 16. Qian Qu, Shuai Gao, Yiming, Li. “Racemic crystal structures of peptide toxins, GsMTx4 prepared by protein total synthesis” (Journal of Peptide Science, 2018, 24, e3112)

¨ 17. Qian Qu^#, Man Pan^#, Shuai Gao, Qingyun Zheng, Yuanyuan Yu, Honggang Hu “A highly efficient synthesis of polyubiquitin chains” (Advanced Science, 2018, 1800234) 

¨ 18. Chenchen Chen, Shuai Gao, Qian Qu, Pengcheng Mi, Anjin Tao, Yiming Li. “Chemical synthesis and structural analysis of guanylate cyclase C agonist linaclotide” (Chinese Chemical Letter, 2018, 29, 1135-1138)

¨ 19. Shan Tang^#, Lujun Liang^#, Yanyan Si^#, Shuai Gao, Jiaxing Wang, Jun Liang, Ziqing Mei, Jishen Zheng, Lei Liu. “Practical chemical synthesis of atypical ubiquitin chains by using an isopeptide-linked Ub isomer” (Angew. Chem. Int. Ed. Engl. 2017, 56, 13333-13337)

· 20. Xiaodan Tan, Man Pan, Shuai Gao, Yong Zheng, Jing Shi, Yiming Li. “A diubiquitin-based photoaffinity probe for profiling K27-linkage targeting deubiquitinases” (Chem. Commun. 2017, 53, 10208-10211)

· 21. Xianglong Tan, Man Pan, Yong Zheng, Shuai Gao, Lujun Liang, Yiming Li. “Sortase-mediated chemical protein synthesis reveals the bidentate binding of bisphosphorylated p62 with K63 diubiquitin” (Chem. Sci. 2017, 8, 6881–6887.)

· 22. Yichao Huang^#, Chenchen Chen^#, Shuai Gao, Yehai Wang, Hua Xiao, Feng Wang, Changlin Tian, Yiming Li. “Synthesis of L- and D-Ubiquitin by One-Pot Ligation and Metal-Free Desulfurization” (Chem. Eur. J. 2016, 22, 7623–7628)

· 23. Huan Lan, Kun Wu, Yong Zheng, Man Pan, Yichao Huang, Shuai Gao, Qingyun Zheng, Jishen Zheng, Yi-Ming Li, Bailong Xiao and Lei Liu. “Total synthesis of mambalgin-1/2/3 by two-segment hydrazide-based native chemical ligation” (J. Pept. Sci. 2016, 22, 320–326)

· 24. Yichao Huang, Chenchen Chen, Sijian Li, Shuai Gao, Jing Shi, Yiming Li. “Facile synthesis of C-terminal peptide hydrazide and thioester of NY-ESO-1 (A39-A68) from an Fmoc-hydrazine 2-chlorotrityl chloride resin” (Tetrahedron, 2014, 70, 2951-2955)