职称：教授
电话：027-69759869
E-mail：lx@whu.edu.cn
通讯地址：武汉大学东湖路185号5号楼7楼
学习经历
1994-1998年毕业于武汉大学生命科学学院94级生物基地班，本科
2000-2005年在武汉大学生命科学学院病毒系，研究生
2005-2008年在哈佛大学医学院，博士后
工作经历
2016年至今 金沙集团wwW3354CC，教授
2009-2016年 金沙集团wwW3354CC，副教授
研究领域
1.肿瘤的血管生成调控机制
2.抗肿瘤药物及相关机制研究
3.抗病毒药物及相关机制研究
研究兴趣与方向
主要方向为治疗肿瘤，抗病毒的蛋白质药物研发
教学课题
细胞生物学（主讲），本科生课程
生物技术制药（主讲），本科生双学位课程
生理生化技术与现代药学研究（主讲），研究生课程
承担课题
主持：武汉大学211人才项目，2010
参加：973计划项目（项目号2010CB529800），2010-2014
主持：国家自然科学基金面上项目（项目号30971456），负责人，2010-2012
主持：武汉大学医学部种子基金，2014
主持：国家自然科学青年基金项目（项目号31400155），负责人，2015-2017
主持：国家自然科学基金面上项目（项目号81472550），负责人，2015-2018
代表性论文
1. Xu J, Jiang Y, Wan L, Wang Q, Huang Z, Liu Y, Wu Y, Chen Z, Liu X*.Feeding recombinant E. coli with GST-mBmKTX fusion protein increases the fecundity and lifespan of Caenorhabditis elegans. Peptides. 2017 Mar;89:1-8.
2. Chen L, Zhang J, Xu J, Wan L, Teng K, Xiang J, Zhang R, Huang Z, Liu Y, Li W, Liu X*. rBmαTX14 Increases the Life Span and Promotes the Locomotion of Caenorhabditis Elegans. PLoS One. 2016 Sep 9;11(9):e0161847.
3. Teng K, Deng C, Xu J, Men Q, Lei T, Di D, Liu T, Li W, Liu X*. Nuclear localization of TEF3-1 promotes cell cycle progression and angiogenesis in cancer. Oncotarget. 2016 Mar 22;7(12):13827-41.（1区TOP，IF 5.998）
4. Chen J, Zhang J, Xiang Y, Xiang L, Liu Y, He X, Zhou X, Liu X*, Huang Z*. Extracts of Tsai Tai (Brassica chinensis): enhanced antioxidant activity and anti-aging effects both in vitro and in Caenorhabditis elegans. Food &Function. 2016 Feb 17;7(2):943-52. （1区TOP，IF 2.795）
5. Qiao C, Jiang Y, Deng C, Huang Z, Teng K, Chen L, Liu X*. Characterization of the transcriptional activation domains of human TEF3-1 (transcription enhancer factor 3 isoform 1). Arch Biochem Biophys. 2015 Mar 1;569:54-61.
6. Liu T, Men Q, Wu G, Yu C, Huang Z, Liu X*, Li W*. Tetrandrine induces autophagy and differentiation by activating ROS and Notch1 signaling in leukemia cells. Oncotarget.2015 Apr 10;6(10):7992-8006.（1区TOP，IF 5.998）
7. Wang H, Liu T, Li L, Wang Q, Yu C, Liu X*, Li W*. Tetrandrine is a potent cell autophagy agonist via activated intracellular reactive oxygen species. Cell Biosci. 2015 Jan 14;5:4.
8. Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, Li W, Liu X*. Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. Int J Oncol.2015,46(1):360-8.
9. Liu X#, Zhao D#, James L, Li J, Zeng H. Requirement of the nuclear localization of transcription enhancer factor 3 for proliferation, migration, tube formation, and angiogenesis induced by vascular endothelial growth factor. FASEB J.2011, 25:1188-97. （#共同第一作者）（2区TOP，IF 5.480）
10. Liu X, Zhao D, Qin L, Li J, Zeng H.Transcription Enhancer Factor 3 (TEF3) Mediates the Expression of Down Syndrome Candidate Region 1 Isoform 1 (DSCR1-1L) in Endothelial Cells. J Biol Chem. 2008, 283:34159-67.（2区TOP，IF 4.477）
11. Liu X#, Zhou W#., Qi Y. Expression of SLAM (CDw150) on SF9 cell surface mediates Measles Viral infection in the nonpermissive cells through SLAM/MVH interaction. Microbes Infect. 2005,7:1235-45.（#共同第一作者）
12. Huang Y#, Liu X#, Dong L, Liu Z, He X, Liu W. Development of viral vectors for gene therapy for chronic pain. Pain Res Treat. 2011, 968218. doi: 10.1155/2011/968218 （#共同第一作者）
13. Yang F, Ai W, Jiang F, Liu X, Huang Z, Ai S, Preclinical Evaluation of an Epidermal Growth Factor Receptor-Targeted Doxorubicin-Peptide Conjugate: Toxicity, Biodistribution, and Efficacy in Mice. Journal of Pharmaceutical Sciences. 2016;105(2):639-649.
14. Mei L, Chen Y, Wang Z, Wang J, Wan J, Yu C, Liu X, Li W. Synergistic anti-tumour effects of tetrandrine and chloroquine combination therapy in human cancer: a potential antagonistic role for p21. Br J Pharmacol. 2015 May;172(9):2232-45.
15. Li J, Chen Y, Wan J, Liu X, Yu C, Li W. ABT-263 enhances sorafenib-induced apoptosis associated with Akt activity and the expression of Bax and p21 (CIP1/WAF1) in human cancer cells. Br J Pharmacol. 2014 Jul;171(13):3182-95.
16. Lei T, Li H, Fang Z, Lin J, Wang S, Xiao L, Yang F, Liu X, Zhang J, Huang Z, Liao W. Polysaccharides from Angelica sinensis alleviate neuronal cell injury caused by oxidative stress.Neural Regen Res. 2014 Feb 1;9(3):260-7.
17. Yi C, Liu X, Liu Y, Lu S, Qi Y. Hemagglutinin protein of measles virus induces apoptosis of HeLa cells via bot extrinsic and intrinsic pathways. Can J Microbiol. 2013 , 59:814-24.
18. Ai S, Jia T, Ai W, Duan J, Liu Y, Chen J, Liu X, Yang F, Tian Y, Huang Z. Targeted delivery of doxorubicin through conjugation with EGF receptor-binding peptide overcomes drug resistance in human colon cancer cells. Br J Pharmacol. 2013 Apr;168(7):1719-35
19. Ai S, Duan J, Liu X, Bock S, Tian Y, Huang Z. Biological evaluation of a novel Doxorubicin-peptide conjugate for targeted delivery to EGF receptor-overexpressing tumor cells. Mol Pharm. 2011, 8:375-86.
